ACUTE DEPLETION OF DIACYLGLYCEROL FROM THE CIS-GOLGI AFFECTS LOCALIZED NUCLEAR ENVELOPE MORPHOLOGY DURING MITOSIS

Acute depletion of diacylglycerol from the cis-Golgi affects localized nuclear envelope morphology during mitosis

Dysregulation of nuclear envelope (NE) assembly results in various cancers; for example, renal and some lung carcinomas ensue due to NE malformation.The NE is a dynamic membrane compartment and its completion during mitosis is a highly regulated process, but the Mouse Pad detailed mechanism still remains incompletely understood.Previous studies hav

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Effect of distance measures on confidences of t-SNE embeddings and its implications on clustering for scRNA-seq data

Abstract Arguably one of the most famous dimensionality reduction algorithms of today is t-distributed stochastic neighbor embedding (t-SNE).Although being widely used for the visualization of scRNA-seq data, it is prone to errors as any algorithm and may lead to inaccurate interpretations of the visualized data.A reasonable way to avoid misinterpr

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An immunohistochemical prostate cell identification key indicates that aging shifts procollagen 1A1 production from myofibroblasts to fibroblasts in dogs prone to prostate-related urinary dysfunction.

BackgroundThe identity and spatial distribution of prostatic cell types has been determined in humans but not in dogs, even though aging- and prostate-related voiding disorders are common in both species and mechanistic factors, such as prostatic collagen accumulation, appear to be shared between species.In this publication we characterize the regi

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